A092.2. Poster board 439 - Mon 10/07, 12:15 - Hall Y
Amadoro G. (1), Ciotti M. T. (1), Costanzi M. (3), Cestari V. (1, 3), Calissano P. (1, 2) & Canu N. (1, 2)
(1) Inst. Neurob. and Mol. Med., CNR, Rome, Italy; (2) Dept. Neurosicence, Univ. Tor Vergata, Rome, Italy; (3) LUMSA Univ, Rome, Italy
- MOLECULAR MECHANISMS UNDERLYING TAU INDUCED NEUROTOXICITY.
A092.3. Poster board 440 - Mon 10/07, 11:30 - Hall Y
Angelo M. (1), Plattner F. (1, 2), Ris L. (3), Strand C. (2), Revesz T. (2), Godaux E. (3), Holton J. L. (2) & Giese K. P. (1)
(1) Wolfson Inst. for Biomed. Research, UCL, London, UK; (2) Inst. of Neurology, UCL, London, UK; (3) Univ. of Mons-Hainaut, Mons, Belgium
- ABSENCE OF NEURODEGENERATION AND BEHAVIOURAL DEFICITS DESPITE TAU HYPERPHOSPHORYLATION IN AGED TRANSGENIC MICE WITH REGIONALLY RESTRICTED P25 EXPRESSION.
A092.4. Poster board 441 - Mon 10/07, 12:15 - Hall Y
Bojarski L. (1), Jozwiak K. (1, 3), Filipek S. (1) & Kuznicki J. (1, 2)
(1) International Inst. of Mol. and Cell. Biol., Warsaw, Poland; (2) Nencki Inst. of Exp. Biol., Warsaw, Poland; (3) Medical Univ. of Lublin, Lublin, Poland
- TOPOLOGY OF CELL MEMBRANE PRESENILIN-1 AND ITS MOLECULAR MODEL IN THE COMPLEX WITH APH-1.
A092.5. Poster board 442 - Mon 10/07, 11:30 - Hall Y
Butovsky O. (1), Ziv Y. (1), Koronyo-Hamaoui M. (1), Landa G. (2), Kunis G. (1), Smirnov I. (3) & Schwartz M. (1)
(1) Department of Neurobiology, Weizmann Institute of Science, Rehovot, Israel; (2) Kaplan Medical Center, Rehovot, Israel; (3) Proneuron Biotechnologies, Ness Ziona, Israel
- IMMUNOMODULATION OF MICROGLIAL PHENOTYPES: IMPLICATIONS FOR MULTIPLE SCLEROSIS AND ALZHEIMER’S DISEASE.
A092.6. Poster board 443 - Mon 10/07, 12:15 - Hall Y
Casamenti F. (1), Bellucci A. (2), Rosi M. C. (1), Grossi C. (1), Luccarini I. (1), Fiorentini A. (1) & Pepeu G. (1)
(1) Dept. Pharmacol., Univ. Florence, Florence, Italy; (2) Dept. Pharmacol., Univ. Brescia, Brescia, Italy
- TAU PROTEIN IS HYPERPHOSPHORYLATED IN THE BRAIN OF 7-MONTH-OLD TGCRND8 TRANSGENIC MICE.
A092.7. Poster board 444 - Mon 10/07, 11:30 - Hall Y
Farinelli M. (2), Knobloch M. (1), Konietzko U. (1), Gretener D. (1), Mansuy I. M. (2) & Nitsch R. M. (1)
(1) Division of Psychiatry Research, Zurich, Switzerland; (2) Brain Research Institute/Swiss Federal Institute of Technolo, Zurich, Switzerland
- ABETA, ARCTIC MUTATION, BEHAVIOURAL DEFICITS, INTRACELLULAR AGGREGATES, ELECTROPHYSIOLOGY.
A092.8. Poster board 445 - Mon 10/07, 12:15 - Hall Y
Gorlovoy P. & Neumann H.
Institute of Reconstructive Neurobiology, Bonn, Germany
- DIMERIZATION OF THE MICROTUBULIN ASSOCIATED PROTEIN TAU INDUCED BY TUMOR NECROSIS FACTOR ALPHA.
A092.9. Poster board 446 - Mon 10/07, 11:30 - Hall Y
Grbic K. (1), Boban M. (1), Hof P. R. (2), Hamann C. (3), Ackl N. (3), Bader B. (4), Danek A. (3) & Simic G. (1)
(1) Croatian Institute for Brain Research, Zagreb, Croatia; (2) Mount Sinai School of Medicine, New York, USA; (3) Neurologische Klinik, Klinikum der Universität München, München, Germany; (4) Zentrum für Neuropathologie und Prionforschung, LMU, München, Germany
- PHOSPHORYLATED TAU EPITOPE THREONIN 231 IN THE EARLY DIAGNOSIS OF ALZHEIMER'S DISEASE.
A092.10. Poster board 447 - Mon 10/07, 12:15 - Hall Y
Grundy R. I. (1), Guillot F. (1), Soden P. (1), Marshall I. (1), Wilson K. L. (1), Collier S. (1), Harrison D. C. (1), Perren M. (1), Pugh P. L. (1), Lawman A. (1), Culbert A. (1), Collins J. L. (2), Irving E. A. (1), Davis J. B. (1) & Richardson J. C. (1).
(1) GlaxoSmothKline, Neurology and GI CEDD, Harlow, UK; (2) GlaxoSmithKline, Discovery Research, North Carolina, USA
- EFFECTS OF LXR AGONISM ON BEHAVIOUR, BETA AMYLOID LEVELS AND MARKERS OF INFLAMMATION IN A TRANSGENIC MOUSE MODEL OF ALZHEIMER’S DISEASE.
A092.11. Poster board 448 - Mon 10/07, 11:30 - Hall Y
Haapasalo A., Kim D. Y., Carey B. W., Pettingell W. H. & Kovacs D. M.
Massachusetts General Hospital, Harvard Med. School, Charlestown Ma, USA
- PROTEOLYTIC CLEAVAGE OF LAR RECEPTOR TYROSINE PHOSPHATASE BY GAMMA-SECRETASE REGULATES ASSOCIATION WITH BETA-CATENIN.
A092.12. Poster board 449 - Mon 10/07, 12:15 - Hall Y
Harrison D. C., Hussain I., Culbert A., Wilson K. L., Lawman A., Collier S., Hawkins J., Davis J. B. & Vinson M.
GlaxoSmithKline, Harlow, UK
- DIFFERENTIAL EFFECTS OF GAMMA SECRETASE INHIBITORS ON AMYLOID BETA AND NOTCH IN ACUTELY TREATED TASTPM MICE.
A092.13. Poster board 450 - Mon 10/07, 11:30 - Hall Y
Härtig W. (1), Stieler J. (1), Boerema A. S. (2), Wolf J. (1), Schmidt U. (1), Strijkstra A. M. (2) & Arendt T. (1)
(1) Paul Flechsig Inst. Brain Res., Univ. Leipzig, Leipzig, Germany; (2) Dept. Animal Behavior, Univ. Groningen, Haren, The Netherlands
- REVERSIBLE TAU HYPERPHOSPHORYLATION IN CHOLINERGIC, BUT NOT GABAERGIC FOREBRAIN NEURONS OF HIBERNATING HAMSTERS: IMPLICATIONS FOR ALZHEIMER'S DISEASE.
A092.14. Poster board 451 - Mon 10/07, 12:15 - Hall Y
Jazi R. (1), Lalonde R. (2), Verdier Y. (1), Howlette D. R. (3) & Strazielle C. (1)
(1) INSERM U724, Lab. Microscopie electronique, Nancy, France; (2) INSERM U614, Rouen, France; (3) NEUROLOGY and GI CEDD, Galaxo Smith Kline Research, Harlow, UK
- BRAIN ACETYLCHOLINESTERASE ACTIVITY IN DOUBLE-MUTANT APP/PS1 (TASTPM) TRANSGENIC MICE.
A092.15. Poster board 452 - Mon 10/07, 11:30 - Hall Y
Jenko Kokalj S. (1), Guncar G. (1), Stern I. (1), Morgan G. (2), Skerget K. (1), Rabzelj S. (1), Kenig M. (3), Turk V. (1), Zerovnik E. (1) & Turk D. (1)
(1) Institute Jozef Stefan, Dept. Biochem. and Mol. Biol., Ljubljana, Slovenia; (2) University of Sheffield, Dept. Mol. Biol. and Biotechnol., Sheffield, UK; (3) University of Zurich, Dept. of Biochem., Zurich, Switzerland
- STRUCTURE OF CYSTATIN B TETRAMER: PROLINES AS SWITCHES IN AMYLOID FIBRIL FORMATION.
A092.16. Poster board 453 - Mon 10/07, 12:15 - Hall Y
Lafay-Chebassier C. (1, 2), Perault M. C. (1, 2), Page G. (1), Rioux Bilan A. (1), Gil R. (1, 2) & Hugon J. (1, 2)
(1) University of Poitiers, Poitiers, France; (2) CHU Poitiers, Poitiers, France
- INVOLVEMENT OF MTOR PATHWAY IN ABETA NEUROTOXICITY.
A092.17. Poster board 454 - Mon 10/07, 11:30 - Hall Y
Lancashire C. L., Mileusnic R. & Rose S. P. R.
Dept. of Biol. Sciences, Open University, Milton Keynes, UK
- COGNITIVE ENHANCING EFFECTS OF D/L ISOMERIC APP-RELATED TRIPEPTIDES ON AMYLOID-BETA INDUCED AMNESIA.
A092.18. Poster board 455 - Mon 10/07, 12:15 - Hall Y
Madani R. (1), Ben Abdallah N. (2), Mohajeri M. H. (4), Wolfer D. P. (2, 3), Vyssotski A. L. (2), Charron Y. (5), Nitsch R. M. (4), Vassalli J. D. (5) & Lipp H. P. (2)
(1) Dept. Basic Neurosci., Univ. of Geneva, Geneva, Switzerland; (2) Institute of Anatomy, Univ. of Zurich, Zurich, Switzerland; (3) Dept. Biol. Swiss Fed. Inst. Technol. Zurich, Zurich, Switzerland; (4) Div. Psychiatr. Res. Univ. of Zurich, Zurich, Switzerland; (5) Med. Genet. Develop. Univ. of Geneva, Geneva, Switzerland
- TISSUE-TYPE PLASMINOGEN ACTIVATOR EXACERBATES MEMORY IMPAIRMENT RELATED TO AMYLOID-BETA TOXICITY IN A MOUSE MODEL OF ALZHEIMER’S DISEASE.
A092.19. Poster board 456 - Mon 10/07, 11:30 - Hall Y
Martinez-Martos J. M., Cobo-Aceituno M. P., De La Chica-Rodriguez S., Cortes-Denia P. & Ramirez-Exposito M. J.
Exp. Clin. Physiopathol. Res. Group CVI-296, Univ. Jaen, Jaen, Spain.
- SERUM PYRROLIDONE CARBOXYL PEPTIDASE ACTIVITY AS A BIOLOGICAL MARKER OF ALZHEIMER'S DISEASE.
A092.20. Poster board 457 - Mon 10/07, 12:15 - Hall Y
Martone R. L. (1), Kreft A. (2), Zhou H. (1), Atchison K. (1), Comery T. (1), Wagner E. (1), Gong X. (1), Aschmies S. (1), Lu P. (1), Sun R. (1), Xu Z. (1), Sonnenberg-Reines J. (1), Ellingboe J. (2), Cole D. (2), Huryn D. (2), Stock J. (2), Harrison B. (2), Reinhart P. (1), Pangalos M. (1) & Jacobsen J. S. (1)
(1) Wyeth Neuroscience Discovery Research, Princeton New Jersey, USA; (2) Wyeth Chemical Sciences, Princeton New Jersey, USA
- A NOVEL, SELECTIVE THIOPHENE SULFONAMIDE INHIBITOR OF APP GAMMA-SECRETASE.
A092.21. Poster board 458 - Mon 10/07, 11:30 - Hall Y
Muntané G., Martínez A., Dalfó E. & Ferrer I.
Univ. de Barcelona, Barcelona, Spain
- GLYCOXIDATIVE AND LIPOXIDATIVE DAMAGE IN PICK’S DISEASE. GFAP IS A TARGET OF GLYCO- AND LIPOXIDATIVE STRESS.
A092.22. Poster board 459 - Mon 10/07, 12:15 - Hall Y
Orzi F. (1), Cavallari M. (1), Iacovelli M. (2), De Blasi M. (4, 5), Giubilei M. (1), Moretti M. (3), De Mattia M. (3), Melchiorri M. (2), Nicoletti M. (2, 5) & Castri M. (1, 6)
(1) Dep Neurol Sci, II Fac Med "La Sapienza", Sant'Andrea Hosp, Rome, Italy; (2) Dep Human Physiol and Pharmacol, Univ "La Sapienza", Rome, Italy; (3) Dep Int Med, Univ "La Sapienza", Rome, Italy; (4) Dep Human Pathol, Univ "La Sapienza", Rome, Italy; (5) I. N. M. Neuromed, Pozzilli, Italy; (6) DiMA, Sant'Andrea Hospital, Rome, Italy
- REDUCED INSULIN-INDUCED PHOSPHATIDYLINOSITOL-3-KINASE ACTIVATION IN ALZHEIMER'S DISEASE.
A092.23. Poster board 460 - Mon 10/07, 11:30 - Hall Y
Page G. (1), Damjanac M. (1), Rioux Bilan A. (1, 2), Pain S. (1, 2), Barrier L. (1), Gil R. (1, 3), Bayer T. (4) & Hugon J. (1, 3)
(1) Research Group on Brain Aging, EA3808, Poitiers, France; (2) Dept. of Pharmacol., University hospital, Poitiers, France; (3) Dept. of Neurol., University hospital, Poitiers, France; (4) Div. of Neurobiol., Dept. of Psychiatry, Saarland, Germany
- ALTERATION OF THE CONTROL OF TRANSLATION IN A NEWLY MODEL OF ALZHEIMER’S DISEASE: APPSL/PS-1 KNOCK IN MICE.
A092.24. Poster board 461 - Mon 10/07, 12:15 - Hall Y
Platt B. (1), Seo S. W. (1, 2), Drever B. (1), Johnson H. (1), Anderson W. (1), Oh Y. S. (2), Choi D. Y. (2) & Riedel G. (1)
(1) School of Med Sci, Aberdeen, UK; (2) LG Life Sciences, Taejon, Korea
- NOVEL BETA SECRETASE INHIBITORS AND HIPPOCAMPAL SIGNALLING AND PLASTICITY.
A092.25. Poster board 462 - Mon 10/07, 11:30 - Hall Y
Ramalho R. M. (1), Castro R. E. (1), Steer C. J. (2), Xin J. (3), Noetzel M. J. (3), Carlson G. A. (4), Ashe K. H. (5), Low W. C. (3) & Rodrigues C. M. P. (1)
(1) C. Patog. Mol., Facul. of Pharm., Univ. of Lisbon, Lisbon, Portugal; (2) Dep. of Med., Univ. of Minnesota Med. School, Minneapolis Mn, USA; (3) Dep. of Neurosurg., Univ. of Minnesota Med. School, Minneapolis Mn, USA; (4) McLaughlin Res. Inst., Great Falls Mt, USA; (5) Dep. of Neurol., Univ. of Minnesota Med. School, Minneapolis Mn, USA
- CONTRIBUTION OF APOPTOSIS TO NEURONAL CELL DEATH IN TRANSGENIC MICE EXPRESSING THE P301L MUTATED FORM OF HUMAN TAU.
A092.26. Poster board 463 - Mon 10/07, 12:15 - Hall Y
Ramirez-Exposito M. J., Cobo-Aceituno M. P., De La Chica-Rodriguez S., Cortes-Denia P. & Martinez-Martos J. M.
Exp. Clin. Physiopathol. Res. Group CVI-296, Univ. Jaen, Jaen, Spain
- PYRROLIDONE CARBOXYL PEPTIDASE TYPE I OVEREXPRESSION IN HUMAN NEUROBLASTOMA NB69 CELL CULTURES PROTECTS AGAINST PYROGLUTAMUYL-ENDED FORMS OF BETA-AMYLOID-INDUCED NEUROTOXICITY.
A092.27. Poster board 464 - Mon 10/07, 11:30 - Hall Y
Restituito S. & Ziff E. B.
Department of Biochemistry, NYU School of Medicine, New York, USA
- GAMMA SECRETASE LOCALIZATION AND FUNCTION AT SYNAPSES.
A092.28. Poster board 465 - Mon 10/07, 12:15 - Hall Y
Rodriguez-Tebar A. (1), Arevalo M. A. (1), Castillo L. (1), Salama-Cohen P. (1) & Grantyn R. (2)
(1) Instituto Cajal-CSIC, Madrid, Spain; (2) Charité, Berlin, Germany
- NGF VERSUS AMYLOID BETA IN ALZHEIMER'S DISEASE.
A092.29. Poster board 466 - Mon 10/07, 11:30 - Hall Y
Sarasa M. & Gallego C.
Lab. Neurobiol., Zaragoza, Spain
- ALZHEIMER-LIKE NEURODEGENERATION AS A PROBABLE CAUSE OF CETACEAN STRANDING.
A092.30. Poster board 467 - Mon 10/07, 12:15 - Hall Y
Schliebs R. (1), Schulze U. (1), Heinitz K. (1), Kouznetsova E. (1), Castro L. (3), Herdegen T. (2) & Peinado M. A. (3)
(1) Paul Flechsig Inst. Brain Res., Dept. Neurochem. Univ Leipzig, Leipzig, Germany; (2) Dept. Pharmacol., Univ. Kiel, Kiel, Germany; (3) Dept. Exp. Biol., Univ. Jaén, Jaén, Spain
- DEVELOPMENTAL PROFILE OF BETA-AMYLOID ACCUMULATION IN CEREBRAL CORTEX IS ALTERED IN TRANSGENIC TG2576 ALZHEIMER-LIKE MICE DEFICIENT OF C-JUN N-TERMINAL KINASE (JNK).
A092.31. Poster board 468 - Mon 10/07, 11:30 - Hall Y
Sipos-Bodo E. (1), Penke Z. S. (1, 2), Kurunczi A. (3), Felszeghy K. (1, 4) & Penke B. (1)
(1) Univ. Of Szeged, Inst. of Med. Chem., Szeged, Hungary; (2) Univ. Of Szeged, Dept. of Comp. Physiol., Szeged, Hungary; (3) Biol. Res. Center of Szeged, Szeged, Hungary; (4) Brain Phys. Res. Group, Hung. Acad. of Sci., Budapest, Hungary
- A POTENTIAL IN VIVO RAT MODEL OF THE ALZHEIMER’S DISEASE.
A092.32. Poster board 469 - Mon 10/07, 12:15 - Hall Y
Underwood C. K., Bartlett P. F. & Coulson E. J.
QBI, Brisbane, Australia
- GAMMA-SECRETASE CLEAVAGE OF P75NTR IS REGULATED BY MOVEMENT INTO LIPID RAFTS, WHICH PROVIDE A PLATFORM FOR DEATH SIGNALLING.
A092.33. Poster board 470 - Mon 10/07, 11:30 - Hall Y
Wan D. C. (1), Leung M. H. (1), Guo M. (1) & Tsim K. W. (2)
(1) Dept of Biochemistry, The Chinese University of Hong Kong, Hong Kong, China; (2) Dept of Biology, Hong Kong Univ. of Science & Technol., Hong Kong, China
- NEUROSIN INCREASES THE AMYLOID PRECURSOR PEPTIDE PROCESSING IN NEUROBLASTOMA CELLS.
A092.34. Poster board 471 - Mon 10/07, 12:15 - Hall Y
Weissmann C., Reyher H. J., Steinhoff H. J. & Brandt R.
University of Osnabrück, Osnabrück, Germany
- CYTOSKELETAL PROTEIN TAU DYNAMICS AS DETERMINED BY PHOTOACTIVATION AND PIXEL ANALYSIS.