A057.2. Poster board 445 - Sun 09/07, 16:45 - Hall Y
Arbuthnott G. (1, 2), Li S. (2) & Jaeger D. (2)
(1) Anatomy, Otago, Dunedin, New Zealand; (2) Biology, Emory, Atlanta, USA
- CORTICAL EFFECTS OF SUBTHALAMIC NUCLEUS STIMULATION: AN INTRACELLULAR STUDY IN ANESTHETIZED RATS.
A057.3. Poster board 446 - Sun 09/07, 16:00 - Hall Y
Bader V. (1), Zhu X. R. (1), Stichel C. C. (1, 2) & Lübbert H. (1, 2).
(1) Ruhr-University-Bochum, Dep. Animal Physiol., Bochum, Germany; (2) Biofrontera Bioscience GmbH, Leverkusen, Germany.
- MITOCHONDRIAL PATHOLOGY IN BIGENIC MOUSE MODELS OF PARKINSON'S DISEASE.
A057.4. Poster board 447 - Sun 09/07, 16:45 - Hall Y
Bjorklund T. (1), Carlsson T. (1), Breysse N. (1), Carta M. (1), Burger C. (2), Mandel R. J. (2), Muzyczka N. (2) & Kirik D. (1)
(1) Wallenberg Neuroscience Center, Lund University, Lund, Sweden; (2) University of Florida, Gainesville, USA
- OPTIMIZATION OF AAV MEDIATED EXPRESSION OF TYROSINE HYDROXYLASE AND GTP CYCLOHYDROLASE 1 FOR CONTINUOUS LEVODOPA PRODUCTION IN VIVO.
A057.5. Poster board 448 - Sun 09/07, 16:00 - Hall Y
Brochard V. F. (1), Prigent A. (1), Flavell R. (2), Duyckaerts C. (1), Hirsch E. C. (1) & Hunot S. (1).
(1) INSERM U679-NEB, Hôpital de la Salpêtrière, Paris, France; (2) Section of Immunobiology, HHMI, Yale University, New Haven, USA.
- LYMPHOCYTES BRAIN INFILTRATION IN PARKINSON'S DISEASE.
A057.6. Poster board 449 - Sun 09/07, 16:45 - Hall Y
Calzarossa C. (1), Zennaro E. (1), Bossolasco P. (2), Armentero M. T. (3), Cova L. (1), Soligo D. (4), Lambertenghi Deliliers G. (4), Polli E. (2), Blandini F. (3) & Silani V. (1).
(1) Dipart. Sci. Neurol., Inst. Auxologico Italiano, Univ. Milan, Milan, Italy; (2) Fondazione Matarelli, Milan, Italy; (3) IRCCS Fond. Inst. Neurol. Mondino, Lab. Neurochimica Funz., Pavia, Italy; (4) UOEmat. 1, Ctr. Trapianti Midollo Osp. Maggiore, Univ. Milan, Milan, Italy.
- MESENCHYMAL STEM CELLS AS A TOOL FOR CELL THERAPY IN A RODENT MODEL OF PARKINSON'S DISEASE (6-HYDROXYDOPAMINE-INDUCED NEURON LESION): AN IN VITRO CHARACTERIZATION AND TOXICITY STUDY.
A057.7. Poster board 450 - Sun 09/07, 16:00 - Hall Y
Falk T., Xie J. Y. & Sherman S. J.
Univ. of Arizona, AHSC, Dept. of Neurology, Tucson, USA
- TISSUE SPECIFIC OVER-EXPRESSION OF INWARDLY RECTIFYING POTASSIUM CHANNELS REDUCES EXCITABILITY IN STRIATAL NEURONS IN VITRO.
A057.8. Poster board 451 - Sun 09/07, 16:45 - Hall Y
Fernandez-Espejo E. (1), Rodriguez De Fonseca F. (2), Ramiro-Fuentes S. (1), Bermudez-Silva F. J. (2), Flores J. A. (1) & Galan-Rodriguez B. (1)
(1) Dept. Fisiologia Medica, Univ. Sevilla, Seville, Spain; (2) Fundacion IMABIS, Malaga, Spain
- OLEYLETHANOLAMIDE, A CANNABINOID ANALOG, SHOWS ANTIOXIDATIVE AND NEUROPROTECTIVE PROPERTIES IN ANIMAL PARKINSONISM.
A057.9. Poster board 452 - Sun 09/07, 16:00 - Hall Y
Fournier M. (1), Saurini F. (1), Hanoun N. (1), Cornilleau F. (1), Joubert F. (1), Languy D. (1), Perez-Diaz F. (1), Goujet-Zalc C. (3), Kahle P. (2), Haass C. (2), Duyckaerts C. (1), Cohen-Salmon C. (1), Hamon M. (1), Brice A. (1) & Corti O. (1).
(1) IFR de Neurosc., Hôp. Pitié-Salpétrière, Paris, France; (2) Ludwig-Maximilians Universität, Munich, Germany; (3) SEAT/UPS44 CNRS, Paris, France.
- MODELING PARKINSON’S DISEASE: EFFECT OF A MUTATED ALPHA-SYNUCLEIN TRANSGENE IN A PARKIN-DEFICIENT MOUSE MODEL.
A057.10. Poster board 453 - Sun 09/07, 16:45 - Hall Y
Golini E., Mandillo S., Marazziti D., Di Pietro C., Matteoni R. & Tocchini-Valentini G. P.
Inst. Cell Biol. CNR, Monterotondo, Italy
- GPR37/PAEL-R INTERACTS WITH THE DOPAMINE TRANSPORTER AND ALTERS DOPAMINERGIC SIGNALLING IN THE NIGRO-STRIATAL PATHWAY.
A057.11. Poster board 454 - Sun 09/07, 16:00 - Hall Y
Gorbatyuk O. S., Nguyen F. N., Manfredsson F. P., Li S., Mandel R. J. & Muzyczka N.
University of Florida, Gainesville, Florida, USA
- INTERACTION OF PHOSPHOLIPASE D2 (PLD2) AND ALPHA-SYNUCLEIN (A-SYN) IN PARKINSON-LIKE NEURODEGENERATION.
A057.12. Poster board 455 - Sun 09/07, 16:45 - Hall Y
Klucken J. (1, 3), Ingelsson M. (2), Frosch M. P. (3), Winkler J. (1), McLean P. (3) & Hyman B. T. (3)
(1) Dep. Neurol., Regensburg, Germany; (2) Dep. Neurol., Uppsala, Sweden; (3) MIND, Boston, USA
- DYSREGULATION OF HEAT SHOCK PROTEINS IN DEMENTIA WITH LEWY BODIES AND THEIR IMPACT ON ALPHA-SYNUCLEIN OLIGOMERISATION, AGGREGATION AND TOXICITY.
A057.13. Poster board 456 - Sun 09/07, 16:00 - Hall Y
Kovar A. (1), Krösser S. (1) & Dolgos H. (2)
(1) Clinical Pharmacology and Pharmacokinetics, Merck KGaA, Darmstadt, Germany; (2) NonClinical Drug Metabolism and Pharmacokinetics, Merck KGaA, Grafing, Germany
- INVESTIGATION ON THE EFFECT OF ERYTHROMYCIN ON THE PHARMACOKINETICS OF SARIZOTAN AND ITS METABOLITES IN HEALTHY MALE VOLUNTEERS.
A057.14. Poster board 457 - Sun 09/07, 16:45 - Hall Y
Krösser S. (1), Fluck M. (2), Wolna P. (3) & Kovar A. (1)
(1) Clinical Pharmacology and Pharmacokinetics, Merck KGaA, Darmstadt, Germany; (2) NonClinical Drug Metabolism and Pharmacokinetics, Merck KGaA, Grafing, Germany; (3) Biostatistics and Data Science, Merck KGaA, Darmstadt, Germany
- INVESTIGATION OF THE ABSOLUTE BIOAVAILABILITY AND THE FOOD EFFECT OF SARIZOTAN.
A057.15. Poster board 458 - Sun 09/07, 16:00 - Hall Y
Lauks J. & Schmidt W. J.
Abt. Neuropharmakologie, Zoologisches Inst., Uni Tuebingen, Tuebingen, Germany
- MDMA REDUCES L-DOPA-INDUCED DYSKINESIA IN PARKINSONIAN RATS.
A057.16. Poster board 459 - Sun 09/07, 16:45 - Hall Y
Matsokis N. (1), Theodoritsi D. (1), Patsoukis N. (4), Antonopoulos I. (2), Panagopoulos N. (1), Margarity M. G. (1), Georgiou C. D. (4) & Anfelatou F. (3).
(1) Hum. Anim. Phys. Lab., Dept. Biology, Univ. Patras, Patras, Greece; (2) Anat. Lab., School of Veterinary Medicine, Aristotle Univ., Thessaloniki, Greece; (3) Phys. Lab, School of Medicine, Univ. Patras, Patras, Greece; (4) Cell Biol. & Dev., Dept. Biology, Univ. Patras, Patras, Greece
- NEUROPROTECTIVE EFFECT OF THE COMBINATION OF N-ACETYLCYSTEINE, ASPIRINE AND 17B –ESTRADIOL ON THE DOPAMINERGIC DEGENERATION IN “WEAVER” MICE.
A057.17. Poster board 460 - Sun 09/07, 16:00 - Hall Y
Monti B., Polazzi E., Batti L., Crochemore C., Bentivogli M., Contestabile A. & Virgili M.
Dept. Biology, Univ. Bologna, Bologna, Italy
- 6-HYDROXYDOPAMINE-INDUCED CEREBELLAR GRANULE DEATH IS MEDIATED BY ALPHA-SYNUCLEIN DOWN-REGULATION AND IS INHIBITED BY MICROGLIAL-SECRETED FACTORS.
A057.18. Poster board 461 - Sun 09/07, 16:45 - Hall Y
Nagel F. (1), Tönges L. (1), Dohm C. P. (1), Wouters F. S. (2), Ganesan S. (2), Bähr M. (1) & Dietz G. P. H. (1)
(1) University of Göttingen, Dept. of Neurology, Göttingen, Germany; (2) Cell Biophysics Group, European Neuroscience Inst., Göttingen, Germany
- TAT-MEDIATED DELIVERY OF HEAT SHOCK PROTEIN 70 IN MODELS OF NEURODEGENERATIVE DISEASES.
A057.19. Poster board 462 - Sun 09/07, 16:00 - Hall Y
Neugebauer R., Krösser S. & Kovar A.
Clinical Pharmacology and Pharmacokinetics, Merck KGaA, Darmstadt, Germany
- INVESTIGATION INTO THE EFFECT OF SARIZOTAN ON THE PHARMACOKINETICS OF L-DOPA AT STEADY-STATE.
A057.20. Poster board 463 - Sun 09/07, 16:45 - Hall Y
Opazo F., Falkengurger B. H. & Schulz J. B.
Dept. of Neurododegeneration & Restorative Research. CMPB, Goettingen, Germany
- UNDERSTANDING THE DICHOTOMY BETWEEN ALPHA-SYNUCLEIN AGGREGATION AND TOXICITY.
A057.21. Poster board 464 - Sun 09/07, 16:00 - Hall Y
Parga-Martin J. A., Lopez-Real A., Rey P., Muñoz A., Rodriguez-Pallares J., Guerra M. J. & Labandeira-Garcia J. L.
Dept. Morphological Sciences, Santiago Compostela, Spain
- REDUCTION OF DOPAMINERGIC DEGENERATION BY INHIBITION OF ANGIOTENSIN-CONVERTING ENZYME IN A 6-HYDROXYDOPAMINE RAT MODEL OF PARKINSONISM.
A057.22. Poster board 465 - Sun 09/07, 16:45 - Hall Y
Popovic N. (1), Svensson A. (1), Fasano S. (2), Brambilla R. (2) & Cenci-Nilsson A. M. (1)
(1) Basal Ganglia Pathophys. Unit, Dept. Exp. Med. Sci., Lund, Sweden; (2) Mol. Gen. Behav. Res. Unit, San Raffaele Res. Inst., Milano, Italy
- ROLE OF THE ERK SIGNALLING PATHWAY IN THE DEVELOPMENT OF L-DOPA-INDUCED DYSKINESIA IN 6-HYDROXYDOPAMINE LESIONED C57/BL6 MICE.
A057.23. Poster board 466 - Sun 09/07, 16:00 - Hall Y
Rodriguez-Pallares J., Muñoz A., Rey P., Parga-Martin J. A., Guerra M. J. & Labandeira-Garcia J. L.
Dept. Morphological Sciences, Santiago Compostela, Spain
- ANGIOTENSIN-CONVERTING ENZYME INHIBITION PROTECTS DOPAMINERGIC NEURONS IN A MPTP MODEL OF PARKINSONISM.
A057.24. Poster board 467 - Sun 09/07, 16:45 - Hall Y
Sarnthein J. (1), Aufenberg C. (1), Morel A. (1), Rousson V. (2) & Jeanmonod D. (1)
(1) Universitätsspital, Zurich, Switzerland; (2) Universität, Zurich, Switzerland
- PALLIDOTHALAMIC TRACTOTOMY IN PARKINSON’S DISEASE: LONG TERM RESULTS.
A057.25. Poster board 468 - Sun 09/07, 16:00 - Hall Y
Singh P. B. (1), Celsi F. (1), Hirschberg H. (2) & Torp R. (1)
(1) Centre for mol. biol and neuroscience, Oslo, Norway; (2) Dep of Neurosurgery, Univ Hospital, Oslo, Norway
- INTRASTRIATAL INFUSION OF GDNF AND BDNF LEADS TO MIGRATION OF SUBVENTRICULAR CELLS AND RECOVERY OF MOTOR BEHAVIOR IN A RAT MODEL OF PARKINSON’S DISEASE.
A057.26. Poster board 469 - Sun 09/07, 16:45 - Hall Y
Tillner J. (1), Krösser S. (1), Fluck M. (2) & Kovar A. (1)
(1) Clinical Pharmacology and Pharmacokinetics, Merck KGaA, Darmstadt, Germany; (2) NonClinical Drug Metabolism and Pharmacokinetics, Merck KGaA, Grafing, Germany
- INVESTIGATION INTO THE EFFECT OF SARIZOTAN ON THE PHARMACOKINETICS AND SAFETY OF DIGOXIN IN HEALTHY MALE VOLUNTEERS.
A057.27. Poster board 470 - Sun 09/07, 16:00 - Hall Y
Yousif N. (1), Bayford R. (2) & Liu X. (1)
(1) Movement Disorder & Neurostimulation Unit, Imperial College, London, United Kingdom; (2) Bio-modelling/Bio-informatics Group, Middlesex University, London, United Kingdom
- A STRUCTURAL MODEL OF THE ELECTRODE-BRAIN INTERFACE IN THERAPEUTIC DEEP BRAIN STIMULATION.
A057.28. Poster board 471 - Sun 09/07, 16:45 - Hall Y
Zennaro E. (1), Armentero M. T. (2), Bossolasco P. (3), Levandis G. (2), Calzarossa C. (1), Cova L. (1), Soligo D. (4), Lambertenghi Deliliers G. (4), Polli E. (3), Silani V. (1) & Blandini F. (2).
(1) Dipart. Sci. Neurol., Inst. Auxologico Italiano, Univ. Milan, Milan, Italy; (2) IRCCS Fond. Inst. Neurol. Mondino, Lab. Neurochimica Funz., Pavia, Italy; (3) Fondazione Matarelli, Milan, Italy; (4) UOEmat. 1, Ctr. Trapianti Midollo Osp. Maggiore, Univ. Milan, Milan, Italy.
- MESENCHYMAL STEM CELLS AS A TOOL FOR CELL THERAPY IN A RODENT MODEL OF PARKINSON'S DISEASE (6-HYDROXYDOPAMINE-INDUCED NEURONAL LESION): A PRELIMINARY IN VIVO STUDY.