A022.2. Poster board 451 - Sun 09/07, 12:15 - Hall Y
Aronin N. (1), Kennington L. (1), Wagh S. (1), Schwarz D. (1), Chase K. (1), Difiglia M. (2), Landwehrmeyer B. (3), Steinbach P. (3), Vonsattel J. P. (4) & Zamore P. D. (1)
(1) Univ. Massachusetts Med. Sch., Worcester, USA; (2) Massachusetts Gen. Hosp., Charlestown, USA; (3) Univ. Ulm, Ulm, Germany; (4) Columbia Univ., New York, USA
- SINGLE NUCLEOTIDE POLYMORPHISMS IN HUNTINGTIN MRNA: FREQUENCY ANALYSIS AND RNAI ALLELE DISCRIMINATION.
A022.3. Poster board 452 - Sun 09/07, 11:30 - Hall Y
Brochier C., De Chaldée M., Aude J. C., Caudy N., Gaillard M. C. & Elalouf J. M.
Bioch. and Mol. Gen. Lab., CEA/DSV/DBJC, Gif-Sur-Yvette, France.
- DETERMINING TRANSCRIPTOME DIFFERENCES BETWEEN BRAIN TERRITORIES.
A022.4. Poster board 453 - Sun 09/07, 12:15 - Hall Y
Ciamei A. & Morton A. J.
Dept. Pharmacol., Univ. Cambridge, Cambridge, United Kingdom
- FUNCTIONAL HIPPOCAMPAL LEARNING MECHANISMS COEXIST WITH STRIATAL FAILURE IN COGNITIVE DEFICITS DEVELOPED BY A TRANSGENIC MOUSE MODEL OF HUNTINGTON’S DISEASE.
A022.5. Poster board 454 - Sun 09/07, 11:30 - Hall Y
Conforti L. (1), Laser H. (2), Beirowski B. (1), Morreale G. (1), Adalbert R. (1), Sorci L. (3), Bridge K. (1), Mack T. (2), Heyer M. (1), Wishart T. M. (4), Haley J. E. (4), Ribchester R. R. (4), Plomann M. (5) & Coleman M. P. (1, 2)
(1) The Babraham Inst., Babraham, Cambridge, United Kingdom; (2) Inst. for Gen. and Cent. for Mol. Med., Cologne, Germany; (3) Inst. of Biochem, Univ. of Ancona, Ancona, Italy; (4) Div. of Neurosc., Univ. of Edinburgh, Edinburgh, United Kingdom; (5) Cent. for Biochem and Cent. for Mol. Med., Cologne, Germany
- FUNCTIONS OF THE SHARED N-TERMINUS OF SLOW WALLERIAN DEGENERATION (WLDS) AND UBE4B PROTEINS: A SEQUENCE REQUIRED FOR AXON PROTECTION AND UBIQUITINATION.
A022.6. Poster board 455 - Sun 09/07, 12:15 - Hall Y
Di Stasi A. M. (1), Metere A. (1), Mallozzi C. (1), Minetti M. (1), Domenici M. R. (2), Pezzola A. (2) & Popoli P. (2)
(1) Dept. of Cell Biol. and Neurosci., ISS, Rome, Italy; (2) Dept. Drug Res. and Eval., ISS, Rome, Italy
- QUINOLINIC ACID MODULATES THE ACTIVITY OF SRC FAMILY KINASES IN RAT STRIATUM: IN VIVO AND IN VITRO STUDIES.
A022.7. Poster board 456 - Sun 09/07, 11:30 - Hall Y
Drew C. J. & Morton A. J.
Univ. of Cambridge, Cambridge, UK
- MICE LACKING COMPLEXIN 1 ARE ATAXIC AND EXHIBIT DEFICITS IN SOCIAL BEHAVIOUR.
A022.8. Poster board 457 - Sun 09/07, 12:15 - Hall Y
García-Martínez J. M. (1), Pérez-Navarro E. (1), Xifró X. (1), Canals J. M. (1), Díaz-Hernández M. (2), Lucas J. J. (2) & Alberch J. (1).
(1) Dpto. Biol. Cel. y Anat. Patol. Fac. Med. UB., Barcelona, Spain; (2) C. Biol. Mol. "Severo Ochoa". CSIC/UAM, Madrid, Spain.
- PROAPOPTOTIC PROTEINS BIM AND BID ARE INVOLVED IN THE NEURONAL DYSFUNCTION IN MOUSE MODELS OF HUNTINGTON'S DISEASE.
A022.9. Poster board 458 - Sun 09/07, 11:30 - Hall Y
Glynn D. & Morton A. J.
University of Cambridge, Cambridge, United Kingdom
- DEFICITS IN INFORMATION PROCESSING AND SOCIAL BEHAVIORS IN THE COMPLEXIN 2 KNOCKOUT MOUSE.
A022.10. Poster board 459 - Sun 09/07, 12:15 - Hall Y
Heng M. & Albin R. L.
University of Michigan, Department of Neurology, Ann Arbor, USA.
- CHARACTERIZATION OF THE HDH(150) CAG MOUSE AS A MODEL OF HUNTINGTON’S DISEASE AND A BIGENIC HDH(150) CAG/NR2B TRANSGENIC CROSS.
A022.11. Poster board 460 - Sun 09/07, 11:30 - Hall Y
Henry R. A. (1, 2), Hughes S. M. (1), Faull R. L. M. (2) & Connor B. (1)
(1) Dept. Pharmacology, University of Auckland, Auckland, New Zealand; (2) Dept. Anatomy, University of Auckland, Auckland, New Zealand
- AAV-MEDIATED DELIVERY OF BDNF AUGMENTS ADULT NEUROGENESIS IN THE NORMAL RAT BRAIN AND IN THE QUINOLINIC ACID LESION MODEL OF HUNTINGTON’S DISEASE.
A022.12. Poster board 461 - Sun 09/07, 12:15 - Hall Y
Li J. Y. (1), Smith R. (1), Chung H. (1), Rundqvist S. (1), Maat-Schieman M. L. C. (2), Colgan L. (3), Englund E. (4), Liu Y. J. (3), Roos R. A. (2), Faull R. L. M. (5) & Brundin P. (1).
(1) NESU, Wallenberg Neuroscience Center, Lund University, Lund, Sweden; (2) Dept. Neurol. LUMC., Leiden, The Netherland; (3) Dept. Neurol. Neurobiol., Univ. Pittsburgh Sch. Med., Pittsburgh, USA; (4) Dept. Clin. Sci., Div V Pathol., Univ. Hospital, Lund, Sweden; (5) Dept. Anat. Radiol., Univ. of Auckland, Auckland, New Zealand
- ABERRANT CHOLINERGIC NEUROTRANSMISSION IN HUNTINGTON’S DISEASE.
A022.13. Poster board 462 - Sun 09/07, 11:30 - Hall Y
Liu W. (1, 2), Wang Y. (1, 2), Wada K. (3), Murata M. (1, 2), Mochizuki H. (3), Wada K. (1, 2) & Kanazawa I. (1, 2)
(1) Solution Oriented Research for Science and Technology, Japan, Saitama, Japan; (2) National Institute of Neuroscience, NCNP, Tokyo, Japan; (3) Res. Inst. for Dis. of Old Age, Juntendo Univ. School of Med, Tokyo, Japan
- RESCUE OF HUNTINGTON’S DISEASE IN MODEL MICE BY RNAI: SHRNA TREATMENTS AT EARLY DEVELOPMENT STAGES YIELD SIGNIFICANTLY BENEFICIAL EFFECTS.
A022.14. Poster board 463 - Sun 09/07, 12:15 - Hall Y
Lukács A., Szabó A. & Vezér T.
Dept. of Public Health, Univ. Szeged, Szeged, Hungary
- ACUTE NEUROBEHAVIOURAL EFFECTS OF SINGLE AND COMBINED ADMINISTRATION OF 3-NP AND MK-801 IN RATS.
A022.15. Poster board 464 - Sun 09/07, 11:30 - Hall Y
Mercer L. D. (1), Kardashyan L. (1, 2), Diwikarla S. (1, 2), Nagley P. (1, 2) & Beart P. M. (1)
(1) Howard Florey Institute, University of Melbourne, Parkville Vic, Australia; (2) Department of Biochemistry and Molecular Biology, Monash Uni, Clayton Vic, Australia
- NEURONAL APOPTOSIS IN CULTURED MURINE GABAERGIC STRIATAL NEURONES: EVIDENCE FOR DIFFERENTIAL RECRUITMENT OF PRO-APOPTOTIC MITOCHONDRIAL SIGNALING.
A022.16. Poster board 465 - Sun 09/07, 12:15 - Hall Y
Metzger S. (1), Bauer P. (1), Tomiuk J. (1), Laccone F. (2), Didonato S. (3), Lange H. W. (4), Weirich-Schwaiger H. (5), Melegh B. (6), Wieczorek S. (7), Zaremba J. (8), Basak A. N. (9), Zidovska J. (10), Pandolfo M. (11), Kadasi L. (12), Kvasnicova M. (13), Weber B. H. F. (14, 15), Kreuz F. (16), Dose M. (17), Stuhrmann M. (18) & Riess O. (1)
(1) Dept. Med. Genet., Tuebingen, Germany; (2) Inst. Hum. Genet., Goettingen, Germany; (3) Natl. Inst. Neurol. Carlo Besta, Milano, Italy; (4) air-Rehazentrum, Duesseldorf, Germany; (5) Dept. Med. Genet., Innsbruck, Austria; (6) Dept. Med. Genet. and Child Development, Pecs, Hungary; (7) Dept. Hum. Genet., Bochum, Germany; (8) Dept. Genet., Warsaw, Poland; (9) Dept. Mol. Biol. Genet., Istanbul, Turkey; (10) Inst. Biol. and Med. Genet., Prague, Czech Republic; (11) Dept. Neurol., Brussels, Belgium; (12) Inst. Mol. Physiol. and Genet., Bratislava, Slovakia; (13) Dept. Clin. Genet., Banska Bystrica, Slovakia; (14) Inst. Hum. Genet., Wuerzburg, Germany; (15) Inst. Hum. Genet., Regensburg, Germany; (16) Dept. Psychiatry, Chemnitz, Germany; (17) BKH-Taufkirchen, Taufkirchen, Germany; (18) Inst. Hum. Genet., Hannover, Germany
- ANALYSIS OF CANDIDATE GENES MODIFYING THE AGE-AT-ONSET IN HUNTINGTON’S DISEASE: RESULTS OF A LARGE EUROPEAN ASSOCIATION STUDY.
A022.17. Poster board 466 - Sun 09/07, 11:30 - Hall Y
Oliveira J. M. A. (1, 2, 4), Chen S. (2), Almeida S. (4), Riley R. (2), Gonçalves J. (1), Oliveira C. R. (4), Hayden M. R. (3), Nicholls D. G. (2), Ellerby L. M. (2) & Rego A. C. (4)
(1) Dep. Pharmacology, Fac. Pharmacy, Univ. Porto, Porto, Portugal; (2) Buck Institute for Age Research, Novato, USA; (3) Dep. Med. Gen., Center Mol. Med. Ther., Univ. Brit. Columbia, Vancouver, Canada; (4) Center for Neuroscience and Cell Biology, Univ. Coimbra, Coimbra, Portugal
- HUNTINGTON’S DISEASE CELLULAR MODELS EXHIBIT AN IMPROVED RECOVERY FROM EXCITOTOXIC STIMULI AFTER TREATMENT WITH HISTONE DEACETYLASE INHIBITORS.
A022.18. Poster board 467 - Sun 09/07, 12:15 - Hall Y
Pallier P., Zheng Z. & Morton A. J.
Dept. of Pharmacology, University of Cambridge, Cambridge, UK
- IMPROVEMENTS IN COGNITIVE FUNCTION IN A TRANSGENIC MOUSE MODEL OF HUNTINGTON’S DISEASE AFTER CHRONIC TREATMENT WITH ALPRAZOLAM ARE DUE TO THE SEDATIVE PROPERTIES OF THE DRUG.
A022.19. Poster board 468 - Sun 09/07, 11:30 - Hall Y
Pang T. Y. C., Howard M. L. & Hannan A. J.
Howard Florey Inst., Melbourne, Australia
- HUNTINGTON'S DISEASE: A GENETIC PRE-DISPOSITION FOR DEPRESSION?
A022.20. Poster board 469 - Sun 09/07, 12:15 - Hall Y
Szabó A., Lukács A. & Papp A.
Department of Public Health, Univ. Szeged, Szeged, Hungary
- ELECTROPHYSIOLOGICAL EFFECTS OF 3-NITROPROPIONIC ACID IN RATS IN DIFFERENT TIMING SCHEMES.
A022.21. Poster board 470 - Sun 09/07, 11:30 - Hall Y
Torres-Peraza J. F., Giralt A., Canals J. M. & Alberch J.
Dpt. Cell Biol. Ant. Pathol. IDIBAPS, Univ. Barcelona, Barcelona, Spain
- BDNF MODULATES EXCITOTOXIC RESISTANCE OF R6/1 HUNTINGTON`S DISEASE MODEL BY REGULATING NMDA RECEPTOR SIGNALING.
A022.22. Poster board 471 - Sun 09/07, 12:15 - Hall Y
Zucker B. (1, 3), Kama J. A. (1), Cantuti-Castelvetri I. (1), Weiller C. (3), Young A. B. (1) & Luthi-Carter R. (2)
(1) Neurology, Mass. Gen. Hospital and Harvard Med. School, Boston, USA; (2) École Polytechnique Fédéral de Lausanne, Lausanne, Switzerland; (3) Neurology, Neurozentrum, Univ. Hospital, Freiburg, Germany
- ALTERED GENE EXPRESSION IN DEEP-LAYER CORTICOSTRIATAL NEURONS OF R6/2 TRANSGENIC MICE AND HUNTINGTON’S DISEASE BRAINS – EVIDENCE FOR DISTURBED POLARITY.