Poster board 515 - Tue 11/07, 16:45 - Hall Y
Session 203 - Psychiatric disorders: others
Abstract A203.6, published in FENS Forum Abstracts, vol. 3, 2006.
Ref.: FENS Abstr., vol.3, A203.6, 2006
|Author(s)||Kopf S., Di Francesco M. C., Casartelli A., Suozzi A., Marini F., Cristofori P., Gerrard P., Heidbreder C. H. & Melotto S.|
|Medicines Res. Centre, Psychiatry CEDD, GlaxoSmithKline SpA, Verona, Italy|
|Title||Ghrelin is involved in stress-induced binge eating in rats exposed to yo-yo dieting.|
|Text||Binge eating is a central feature of human eating disorders and recent studies have highlighted significant co-morbidities with depression, obsessive-compulsive disorders, drug abuse, and anxiety. In order to explore the pathophysiology of binge eating and to assess the potential therapeutic profile of novel drugs a preclinical model was developed (Hagan et al, 2002). Accordingly, this study aimed to assess the effect of dieting on selected physiological parameters and the relationship with the binge behaviour observed after exposure to acute stress.
Female Sprague-Dawley rats were exposed to restricted diet (4 days) and food ad libitum (4 days); this cycle was repeated 3 times. Following the last day of re-feeding, rats received a stress stimulus (foot-shock on day 24).
Food restriction (R) caused a significant decrease in alanine aminotransferase, urea, glucose and triglycerides, and a significant increase in bilirubin. These changes were no longer observed after refeeding (comparable body weight to control animals, day 24). After shock, only the restricted and stressed (R/S) group showed a significant increase in food intake compared to the other 3 groups (NR/NS, NR/S and R/NS) (Dunnett?s test, p=0.002). Among the hormones analysed, significant (p=0.05) changes were detected for ghrelin and leptin, in the R groups (+49%; -31%, respectively), and for Corticosterone and ACTH in the stressed (S) groups (+41%; +59%, respectively). No significant differences were found in serum levels of growth hormone, prolactin, insulin, glucagon or glucose among the different groups. Moreover, the data showed a trend of stress and food restriction interaction in ghrelin and corticosterone levels.
Considering that ghrelin levels have been hypothesised to be one of the main drivers of human eating disorders and patients'binge behaviour, our data suggest that the binge eating model could be useful to study alterations in eating behaviour in stress-related disorders.
|Theme||Neurological and psychiatric conditions
Psychiatric disorders / Other